GEM Core: Nutrigenomics
GEM Core: Nutrigenomics is an all-encompassing support system for investigators conducting research on nutrigenomic aspects of nutrition and obesity.
About
The nutrigenomics component of the Genomics and Energy Metabolism (GEM) Core offers laboratory services as well as customized, cutting-edge research tools, including 1) whole genome, exome, and targeted gene sequencing; 2) RNA-sequencing; 3) targeted genotyping using PCR-based assays; 5) array-based gene expression profiling; 6) and bisulfide sequencing for methylation patterns in humans and mouse models. The Core provides investigators with the expertise and resources necessary to investigate the role of host genetic factors in biological responses to nutritional exposure. The mission of the Core is to provide a suite of precision nutrition services that enable investigators to integrate nutrigenomics into nutrition and obesity research to advance our understanding of how individual genetics influence individual variability related to nutritional exposures and adiposity.
GEM Core: Nutrigenomics also facilitates facilitates collaborations with the Gnotobiotic Core, the High-Throughput Sequencing Facility, and the Mammalian Genotyping Core at UNC.
GEM Core: Microbiome provides microbiome services through the UNC Microbiome Core Facility.
Services
GEM Core: Nutrigenomics offers a variety of services. To learn more about a specific service and/or to submit a service request, visit us on iLab.
- Lab Analysis
- DNA/RNA extractions: isolate DNA/RNA from blood, saliva, tissue, or blood spots to analyze SNPs
- Concentrating DNA samples, PCR runs, gels
- Data Cleaning/Mining; Interpretation of Results; Tabulation and Graphical Representation of Results
- One-Carbon Metabolism SNP Chip Microarray: One-Carbon Metabolism SNP Chip Microarray: This is the MEGAEX microarray (illumina) containing over 2 million human SNPs including many related to one-carbon metabolism, (e.g.: PEMT rs12325817, CHDH rs12676 and CHDH rs9001).
- Variant Identification and Annotation
- Genome-Wide Linkage Analysis
- Multipoint Identity by Descent (MIBD) Determination
- Genome-Wide SNP or Whole Genome Sequence Association Analysis, Genome-Wide Transcriptional Data Analysis
- Haplotype Inference, Genotype and Phenotype Imputation
- Nutrigenetics and Nutrigenomics Data Analysis/Consulting
- Proofreading of Manuscript/Grant Proposals; Imputation; Estimation of Kinships and Pedigrees in Related Samples
- Grant Development Assistance
Contact
Saroja Voruganti, PhD
Associate Professor, Nutrition
Nutrition Research Institute
500 Laureate Way, Suite 3150
Kannapolis, NC 28081
saroja@unc.edu
Director, Genomics and Energy Metabolism Core
Ian Carroll, PhD
Assistant Professor, Nutrition
111 Mason Farm Road , 7312C MBRB Building
CB# 7032
Chapel Hill, NC 27599
ian_carroll@med.unc.edu
Co-Investigator, GEM Core: Microbiome
M. Andrea Azcarate-Peril, PhD
Associate Professor, Medicine
Director, UNC Microbiome Core Facility (GEM Core: Microbiome)